International Journal of Pharmacy and Pharmaceutical Sciences
ISSN- 0975-1491 Vol 2, Suppl 2, 2010
ANTIGLAUCOMATIC NIOSOMAL SYSTEM: RECENT TREND IN OCULAR DRUG DELIVERY RESEARCH
SAYON PAUL, RANJIT MONDOL, SOMDIPTA RANJIT, SABYASACHI MAITI* Gupta College of Technological Sciences, Department of Pharmaceutics, Ashram More, G.T. Road, Asansol713301, West Bengal, India. E mail:email@example.com Received: 27 Jan 2010, Revised and Accepted: 16 Feb 2010 ABSTRACT Glaucoma is a disease and characterized by an intraocular pressure higher than the eye can tolerate. The chronic glaucoma with open angle creates a major problem of public health and it is the second leading cause of blindness in the world. Because of the constraints of physiological factors such as lachrymal drainage, lower culdesac volume, reflex tearing, drug spillage, and lower corneal permeability onto the cheek; the ocular bioavailability of conventional ophthalmic preparations is very poor. Conventional preparations require frequent instillation, and long term use of such preparations can cause ocular surface disorders. In recent years, significant efforts have been directed towards the development of new carrier systems for ocular drug delivery. Among these, non‐ionic surfactant vesicles i.e. niosomes could be a potential one for the effective treatment of glaucoma patients and have gained popularity in ocular drug delivery research. This article reviews the constraints of conventional ocular therapy, complications of glaucoma therapy, and newer advances in the field of anti‐glaucomatic niosomal formulation. Keywords: Niosomes, Glaucoma, Ocular delivery, Eye drops. INTRODUCTION Eye is the most important and sensitive organ; in fact, it is the window of our soul. The eye is unique organ from anatomical and physiological point of view. The eye has special attributes that ...