Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

Maternal Exercise during Pregnancy Increases BDNF Levels and Cell Numbers in the Hippocampal Formation but Not in the Cerebral Cortex of Adult Rat Offspring

RESEARCH ARTICLE

Maternal Exercise during Pregnancy
Increases BDNF Levels and Cell Numbers in
the Hippocampal Formation but Not in the
Cerebral Cortex of Adult Rat Offspring
Sérgio Gomes da Silva1,2,3*, Alexandre Aparecido de Almeida1, Jansen Fernandes1,
Glauber Menezes Lopim1, Francisco Romero Cabral2, Débora Amado Scerni4, Ana
Virgínia de Oliveira-Pinto5, Roberto Lent5, Ricardo Mario Arida1*

a11111

1 Departamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo—SP, Brazil,
2 Hospital Israelita Albert Einstein, São Paulo—SP, Brazil, 3 Universidade de Mogi das Cruzes (UMC), Mogi
das Cruzes—SP, Brazil, 4 Disciplina de Neurologia Experimental, Universidade Federal de São Paulo
(UNIFESP), São Paulo—SP, Brazil, 5 Instituto de Ciências Biomédicas, Universidade Federal do Rio de
Janeiro (UFRJ), Rio de Janeiro—RJ, Brazil
* sgomesilva@hotmail.com; arida.nexp@epm.br

OPEN ACCESS
Citation: Gomes da Silva S, de Almeida AA,
Fernandes J, Lopim GM, Cabral FR, Scerni DA, et al.
(2016) Maternal Exercise during Pregnancy
Increases BDNF Levels and Cell Numbers in the
Hippocampal Formation but Not in the Cerebral
Cortex of Adult Rat Offspring. PLoS ONE 11(1):
e0147200. doi:10.1371/journal.pone.0147200
Editor: Georges Chapouthier, Université Pierre et
Marie Curie, FRANCE
Received: August 26, 2015
Accepted: December 30, 2015
Published: January 15, 2016
Copyright: © 2016 Gomes da Silva et al. This is an
open access article distributed under the terms of the
Creative Commons Attribution License, which permits
unrestricted use, distribution, and reproduction in any
medium, provided the original author and source are
credited.
Data Availability Statement: All relevant data are
within the paper and its Supporting Information files.
Funding: Research supported by Conselho Nacional
de Desenvolvimento Científico e Tecnológico (CNPq),
Coordenação de Aperfeiçoamento de Pessoal de
Nível Superior (CAPES), Fundação de Amparo à...

Similar Essays