458
Cell 159, October 9, 2014 ©2014 Elsevier Inc.
DOI http://dx.doi.org/10.1016/j.cell.2014.09.037
See online version for for legend and references.
H
NH2
NH
NH
NH2
Ph
NH
NH
NH
O
RCit
H2N
KBu
HN
O
N
KHib
HN
S/T/YPh
-
O O P O
O
KCr
O
HN
HPh
Og
O
O
-
Me
Ac Me
Hib Ac
Ub Ar
HN
O
O
-
Ubiquitin
Ph
Me
Ac
Hib
Me Fo
S/TOg
OH
OH
OH
KUb
A cHN
O
HN
O
Me/Ac/Pr/Cr/Hib
Su/Ma/Fo /Ub
OH
OH
Ph
YOH
KSu
O
Me Ph Me
O N P O
O -
KMa
O
O N
N P O
O -
OH
Me
Me/Ac/Bu/Cr
Me/Ac/Bu/Cr
Ac
Me/Ac/Bu Hib/Fo /Ub Me/Ac/Pr/Bu/Cr Hib/Su/Ub/Ar
Bu Ac Hib/Su/Ub
Hib/Su/
Fo
/
Ub
Me
Me Cr Ph
Me
Ac
Cit
Cit Hib Og Ph
Cit
Ph
Ac
HN
+
HN
O
+
H
N
+
O
+
Me
Ph
K/EAr
OH OH
N
O
Ph
N
N
N
N
NH2
Ac
Bu
Me
Ac
Pr
Bu
Cr
Hib
Ma
Su
Fo
Ub
Cit
Ph
OH
Og
Ar
Me/Ac/Bu/Cr
Hib/Su/Fo/Ub
+ Positive change
- Negative charge
OH OH
O
S/TAc
O
O
O
O P O P O
OH OH
KMe
Me/Ac/Bu/Cr
Hib/Su/Fo /Ub
Ac
Ph
N/O
H2N
Me
Methylation (K, R)
Acetylation (K, S, T)
Propionylation (K)
Butyrylation (K)
Crotonylation (K)
2-Hydroxyisobutyrylation (K)
Malonylation (K)
Succinylation (K)
Formylation (K)
Ubiquitination (K)
Citrullination (R)
Phosphorylation (S, T, Y, H)
Hydroxylation (Y)
O-GlcNAcylation (S, T)
ADP ribosylation (K, E)
Ph
Me
Cit
Me/Ac/Pr
Bu/Cr/Hib
Ac/Pr/Bu
Cr/Hib
10
Me/Ac/Pr/Bu
Cr/Hib/Su/Fo
Me Me
Me
Cit Ph Cit Ac
Me/Ac/Pr/Bu
Cr/Hib/Ar
20
Me
Me/Ac/Pr/Bu
Hib/Su/ Fo /Ub
30
Me
Pr
Bu
Hib
40
Ph
Og
Ph
OH
Me
55
Me
Cr
Hib
Fo
Ub
62
Me
78
106
Ph
Ph
Me
Me/Ac/Pr/Bu/Cr Me/Ac/Pr/Bu
Hib/Su/Fo /Ub Hib/Su/Fo
80
114
Ph
OH
127
Me
Ac/Pr/Bu/Cr
Hib/Su/ Fo /Ub
121
130
RTKQTARKSTGG KAP RKQLA TKAA RKSAPA...