Review
37
38
39
40
41
42
43
pre-eclampsia/eclampsia in Australian women.
Gynecol. Obstet. Invest. 50, 100–102
Laivuori, H. et al. (2000) 677 C→T polymorphism of
the methylenetetrahydrofolate reductase gene and
preeclampsia. Obstet. Gynecol. 96, 277–280
Chen, J. et al. (1999) MTHFR polymorphism,
methyl-replete diets and the risk of colorectal
carcinoma and adenoma among U.S. men and
women: an example of gene–environment
interactions in colorectal tumorigenesis.
J. Nutr. 129, 560S–564S
Levine, A.J. et al. (2000) The methylenetetrahydrofolate reductase 677C→T polymorphism
and distal colorectal adenoma risk. Cancer
Epidemiol. Biomarkers Prev. 9, 657–663
Slattery, M.L. et al. (1999) Methylenetetrahydrofolate reductase, diet, and risk of colon
cancer. Cancer Epidemiol. Biomarkers Prev. 8,
513–518
Ulrich, C.M. et al. (1999) Colorectal adenomas and
the C677T MTHFR polymorphism: evidence for
gene–environment interaction? Cancer Epidemiol.
Biomarkers Prev. 8, 659–668
Ulvik, A. et al. Smoking, folate and
methylenetetrahydrofolate reductase status as
interactive determinants of adenomatous and
hyperplastic polyps of colorectum. Am. J. Med.
Genet. (in press)
Kim, Y.I. (2000) Methylenetetrahydrofolate
reductase polymorphisms, folate, and cancer risk: a
paradigm of gene–nutrient interactions in
carcinogenesis. Nutr. Rev. 58, 205–209
TRENDS in Pharmacological Sciences Vol.22 No.4 April 2001
44 Mahmud, N. et al. (1999) Increased prevalence of
methylenetetrahydrofolate reductase C677T
variant in patients with inflammatory bowel
disease, and its clinical implications. Gut 45,
389–394
45 Nielsen, J.N. et al. (2000) Increased prevalence of
methylenetetrahydrofolate reductase C677T
variant in patients with IBD. Gut 47, 456–457
46 Vecchi, M. et al. (2000) Inflammatory bowel diseases
are not associated with major hereditary conditions
predisposing to thrombosis. Dig. Dis. Sci. 45,
1465–1469
47 Yoo, J.H. et al. (2000)...