einleinasihgapoodsf

einleinasihgapoodsf

458

Cell 159, October 9, 2014 ©2014 Elsevier Inc.

DOI http://dx.doi.org/10.1016/j.cell.2014.09.037

See online version for for legend and references.

H

NH2

NH

NH

NH2

Ph

NH

NH
NH

O

RCit

H2N

KBu

HN

O

N

KHib

HN

S/T/YPh

-

O O P O
O

KCr

O
HN

HPh

Og

O
O

-

Me
Ac Me
Hib Ac
Ub Ar

HN
O

O

-

Ubiquitin

Ph

Me
Ac
Hib
Me Fo

S/TOg

OH
OH

OH

KUb

A cHN

O

HN

O

Me/Ac/Pr/Cr/Hib
Su/Ma/Fo /Ub

OH

OH

Ph

YOH

KSu

O

Me Ph Me

O N P O
O -

KMa

O

O N
N P O
O -

OH

Me
Me/Ac/Bu/Cr
Me/Ac/Bu/Cr
Ac
Me/Ac/Bu Hib/Fo /Ub Me/Ac/Pr/Bu/Cr Hib/Su/Ub/Ar
Bu Ac Hib/Su/Ub
Hib/Su/
Fo
/
Ub
Me
Me Cr Ph
Me
Ac
Cit
Cit Hib Og Ph
Cit
Ph
Ac

HN

+

HN

O

+

H
N

+

O

+

Me

Ph

K/EAr

OH OH

N

O

Ph

N

N
N

N

NH2

Ac
Bu

Me
Ac
Pr
Bu
Cr
Hib
Ma
Su
Fo
Ub
Cit
Ph
OH
Og
Ar

Me/Ac/Bu/Cr
Hib/Su/Fo/Ub

+ Positive change
- Negative charge

OH OH

O

S/TAc

O

O
O
O P O P O
OH OH

KMe

Me/Ac/Bu/Cr
Hib/Su/Fo /Ub
Ac
Ph

N/O

H2N

Me

Methylation (K, R)
Acetylation (K, S, T)
Propionylation (K)
Butyrylation (K)
Crotonylation (K)
2-Hydroxyisobutyrylation (K)
Malonylation (K)
Succinylation (K)
Formylation (K)
Ubiquitination (K)
Citrullination (R)
Phosphorylation (S, T, Y, H)
Hydroxylation (Y)
O-GlcNAcylation (S, T)
ADP ribosylation (K, E)

Ph

Me
Cit

Me/Ac/Pr
Bu/Cr/Hib

Ac/Pr/Bu
Cr/Hib

10

Me/Ac/Pr/Bu
Cr/Hib/Su/Fo
Me Me
Me
Cit Ph Cit Ac

Me/Ac/Pr/Bu
Cr/Hib/Ar

20

Me

Me/Ac/Pr/Bu
Hib/Su/ Fo /Ub

30

Me

Pr
Bu
Hib

40

Ph
Og

Ph
OH
Me

55
Me
Cr
Hib
Fo
Ub

62

Me

78

106

Ph

Ph

Me

Me/Ac/Pr/Bu/Cr Me/Ac/Pr/Bu
Hib/Su/Fo /Ub Hib/Su/Fo

80

114

Ph
OH

127

Me

Ac/Pr/Bu/Cr
Hib/Su/ Fo /Ub

121

130

RTKQTARKSTGG KAP RKQLA TKAA RKSAPA...