CNV-1014802 (Neuropathic Pain) - Forecast and Market Analysis to 2022
Neuropathic pain (NP) is defined as a disorder of the sensorimotor system and is distinctly different from nociceptive pain, which is a consequence of trauma, injury, or inflammation. The main difference between neuropathic and nociceptive pain is the absence of a continuous nociceptive input in neuropathic pain. Although the term neuropathic pain is used to describe a wide range of pain syndromes with varying etiologies, this report focuses on 3 distinct forms of NP: Painful diabetic neuropathy, Postherpetic neuralgia and trigeminal neuralgia. The main classes of drugs used to treat these three neuropathic pain indications include anticonvulsants, antidepressants, opioids and topical treatments. However, despite the availability of multiple pain medications only 50% of patients respond to any given drug and there are numerous the side effects associated particularly with systemically administered drugs, that reduce their tolerability. New treatments will target some key unmet needs in terms of efficacy and tolerability, but opportunities will remain for drugs that can more reliably eradicated NP in targeted patient populations, as well as offering an improved safety profile.
CNV-1014802 is a novel therapy being developed by Convergence Pharmaceuticals for the treatment of pain associated with entrapment neuropathies, such as lumbosacral radiculopathy and TN. Like CNV-2197944, CNV-1014802 was acquired from GSK in 2010 as part of an agreement in which the company acquired an 18% minority equity stake in Convergence Pharmaceuticals. CNV-1014802 is a small molecule that blocks the Nav1.7 sodium channels, which are involved in transmitting pain signals. It was demonstrated in experimental models to block the high frequency and spontaneous neuronal firing that is often characteristic of TN.
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