• The Arbovirus are also called as
Arthropod borne viruses, represent an
ecological grounding of viruses with
complex transmission cycles involving
• These viruses have diverse physical and
chemical properties and are classified in
several virus families.
• Dengue infection is caused by
History - Dengue
• This disease was first described 1780, and the
virus was isolated by Sabin 1944. Dengue virus
infection is the most common arthropodborne disease worldwide with an increasing
incidence in the tropical regions of Asia,
Africa, and Central and South America. There
are four serotypes of the virus. All are
transmitted by mosquitoes, which are not
affected by the disease, although an infected
mosquito may infect others (not via man).
Over view of Dengue
• With more than one-third of the world’s
population living in areas at risk for
transmission, dengue infection is a
leading cause of illness and death in the
tropics and subtropics. As many as 100
million people are infected yearly.
Dengue is caused by any one of four
related viruses transmitted by
• Dengue is the biggest Arbovirus problem in the world today with
over 2 million cases per year. Dengue is found in SE Asia, Africa and
the Caribbean and S America.
• Flavivirus, 4 serotypes, transmitted by Aedes mosquitoes which reside
in water-filled containers.
• Human infections arise from a human-mosquitoe-human cycle
• Classically, dengue presents with a high fever, lymphadenopathy,
myalgia, bone and joint pains, headache, and a Maculopapular rash.
• Severe cases may present with hemorrhagic fever and shock with a
mortality of 5-10%. (Dengue hemorrhagic fever or Dengue shock
• In the 1980s, DHF began a second expansion
into Asia when Sri Lanka,...